Commentary: engrailed 1 shapes the dopaminergic and serotonergic landscape through proper Iso maintenance and function

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Engrailed 1 shapes the dopaminergic and serotonergic landscape through proper isthmic organizer maintenance and function.

The isthmic organizer (IsO) is a signaling center that specifies the correct and distinct embryonic development of the dopaminergic midbrain and serotonergic hindbrain. The IsO is a linear boundary between the two brain regions, emerging at around embryonic day 7-8 of murine embryonic development, that shapes its surroundings through the expression of instructive signals such as Wnt and growth ...

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ژورنال

عنوان ژورنال: Journal of Neurology and Neuromedicine

سال: 2016

ISSN: 2572-942X

DOI: 10.29245/2572.942x/2016/5.1036